Recent Publications


Sphingolipids and phospholipids in insulin resistance and

related metabolic disorders.

Meikle PJ, Summers SA.

Nature reviews. Endocrinology. 2017; 13(2):79-91.

PMID: 27767036


Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism.

Chaurasia B, Kaddai VA, Lancaster GI, Henstridge DC, Sriram S, Galam DL, Gopalan

V, Prakash KN, Velan SS, Bulchand S, Tsong TJ, Wang M, Siddique MM, Yuguang G,

Sigmundsson K, Mellet NA, Weir JM, Meikle PJ, Bin M Yassin MS, Shabbir A, Shayman

JA, Hirabayashi Y, Shiow ST, Sugii S, Summers SA.

Cell metabolism. 2016; 24(6):820-834.

PMID: 27818258


A Role for Ceramides, but Not Sphingomyelins, as Antagonists of Insulin Signaling and Mitochondrial Metabolism in C2C12 Myotubes.

Park M, Kaddai V, Ching J, Fridianto KT, Sieli RJ, Sugii S, Summers SA.

The Journal of biological chemistry. 2016; 291(46):23978-23988.

PMCID: PMC5104923


Rebuttal from Scott A. Summers and Bret H. Goodpaster.

Summers SA, Goodpaster BH.

The Journal of physiology. 2016; 594(12):3175-6.

PMCID: PMC4800026


CrossTalk proposal: Intramyocellular ceramide accumulation does modulate insulin resistance.

Summers SA, Goodpaster BH.

The Journal of physiology. 2016;594(12):3167-70.

PMCID: PMC4800028


ECM microenvironment unlocks brown adipogenic potential of adult human bone marrow-derived MSCs.

Lee MH, Goralczyk AG, Kriszt R, Ang XM, Badowski C, Li Y, Summers SA, Toh SA,

Yassin MS, Shabbir A, Sheppard A, Raghunath M.

Scientific reports.2016; 6:21173.

PMCID: PMC4756694


Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo.

Bharath LP, Ruan T, Li Y, Ravindran A, Wan X, Nhan JK, Walker ML, Deeter L,

Goodrich R, Johnson E, Munday D, Mueller R, Kunz D, Jones D, Reese V, Summers SA,

Babu PV, Holland WL, Zhang QJ, Abel ED, Symons JD.

Diabetes. 2015; 64(11):3914-26.

PMCID: PMC4613970


Ceramides - Lipotoxic Inducers of Metabolic Disorders.

Chaurasia B, Summers SA.

Trends in endocrinology and metabolism: TEM. 2015; 26(10):538-50.

PMID: 26412155


The ART of Lowering Ceramides.

Summers SA.

Cell metabolism. 2015; 22(2):195-6.

PMID: 26244926


Dihydroceramides: From Bit Players to Lead Actors.

Siddique MM, Li Y, Chaurasia B, Kaddai VA, Summers SA.

The Journal of biological chemistry. 2015;290(25):15371-9.

PMCID: PMC4505450


Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial

respiration and cancer cell metabolism.

Teh JT, Zhu WL, Ilkayeva OR, Li Y, Gooding J, Casey PJ, Summers SA, Newgard CB,

Wang M.

Oncogene. 2015; 34(25):3296-304.

PMID: 25151967


Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.

Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J,

Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ,

Symons JD, Summers SA, Oresic M, Vidal-Puig A.

Diabetes. 2015; 64(4):1180-92.

PMID: 25352638


Essential nutrient supplementation prevents heritable metabolic disease in multigenerational intrauterine growth-restricted rats.

Goodspeed D, Seferovic MD, Holland W, Mcknight RA, Summers SA, Branch DW, Lane

RH, Aagaard KM.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015; 29(3):807-19.

PMCID: PMC4422359


Molecular pathways reflecting poor intrauterine growth are found in Wharton's jelly-derived mesenchymal stem cells.

Sukarieh R, Joseph R, Leow SC, Li Y, Löffler M, Aris IM, Tan JH, Teh AL, Chen L,

Holbrook JD, Ng KL, Lee YS, Chong YS, Summers SA, Gluckman PD, Stünkel W.

Human reproduction (Oxford, England). 2014;29(10):2287-301.

PMID: 25129543


CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to

diet-induced steatohepatitis and insulin resistance.

Raichur S, Wang ST, Chan PW, Li Y, Ching J, Chaurasia B, Dogra S, Öhman MK,

Takeda K, Sugii S, Pewzner-Jung Y, Futerman AH, Summers SA.

Cell metabolism. 2014;20(4):687-95.

PMID: 25295789


Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice.

Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y, Ilkayeva OR, Gooding J,

Ching J, Zhou J, Martinez L, Xie S, Bay BH, Summers SA, Newgard CB, Yen PM.

Hepatology (Baltimore, Md.). 2014; 59(4):1366-80.



Ceramides and glucosylceramides are independent antagonists of insulin signaling.

Chavez JA, Siddique MM, Wang ST, Ching J, Shayman JA, Summers SA.

The Journal of biological chemistry. 2014; 289(2):723-34.

PMCID: PMC3887200


Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans.

Chua EC, Shui G, Lee IT, Lau P, Tan LC, Yeo SC, Lam BD, Bulchand S, Summers SA,

Puvanendran K, Rozen SG, Wenk MR, Gooley JJ.

Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(35):14468-73.

PMCID: PMC3761633


Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling.

Siddique MM, Li Y, Wang L, Ching J, Mal M, Ilkayeva O, Wu YJ, Bay BH, Summers SA.

Molecular and cellular biology. 2013; 33(11):2353-69.

PMCID: PMC3648062




For a complete listing of Scott Summers' publications, please visit his NCBI bibliography