The major accomplishment of our laboratory is advancing the idea that sphingolipids (e.g. ceramides) contribute to insulin resistance and metabolic disease. This prior work involving cell culture and rodent model systems has revealed considerable new mechanistic insight into the role of these molecules as central regulators of nutrient homeostasis. This focus on basic science and discovery biology will continue to be a major component of our laboratory. However, we now endeavor to also translate these findings into new clinical procedures or behavioral interventions to improve health.